Structural Biology / Biophysics: Guillermo Montoya, Alex Toftgaard Nielsen, Thue Schwartz, Josh Brickman, Elke Ober, Jakub Sedzinski, Nicholas Taylor, Ditte Hededam Welner, Thomas Frimurer In addition to my responsibilities as an Associate Professor, I am a co-founder of Ankrin Theapeutics, a company developing innovation in the field of cancer therapy. The Frimurer Group investigates how small molecules and drugs interact with target proteins to modulate their function, with special interest in translational pharmacology and rational design of next generation drugs. She has received several prestigious awards, including the Danish Cancer Society Junior Research Prize (2011), the Heirloom Award for Women Scientist Leaders (2014) and the Elite Research Prize by the Danish Ministry of Higher Education and Science (2018). Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1 Michael Lückmanna,b, Mette Trauelsena, Marie A. Bentsena, Tinne A. D. Nissena, Joao Martinsc, Zohreh Fallaha,d, Mads M. Nygaarde, Elena Papaleoe,f, Kresten Lindorff-Larsenc, Thue W. Schwartza,b, and Thomas M. Frimurera,f,1 aNovo Nordisk Foundation Center for Basic Metabolic Resear ch, University of … Here the authors present aprepitant bound NK1R crystal structures and use NMR spectroscopy to … Most downloaded Dr. Frimurer, who has 15+ years of experience with structure-based chemical design technologies in academia and Pharma/Biotech, is head of a group focusing at Chemical and Molecular Receptology (computational chemistry). Frimurer, who has 15+ years of experience with structure-based chemical design technologies in academia and Pharma/Biotech, is head of a group focusing at Chemical and Molecular Receptology (computational chemistry). Lukas and Bartek. Following post-doctoral positions at Novo Nordisk A/S and Harvard University, Thomas Frimurer worked in positions as Principal Scientist at 7TM Pharma and at the NNF Center for Protein Research. Structural Biology / Biophysics: Guillermo Montoya, Alex Toftgaard Nielsen, Thue Schwartz, Josh Brickman, Elke Ober, Jakub Sedzinski, Nicholas Taylor, Ditte Hededam Welner, Thomas Frimurer Despite the recent determination of its 2.9 Å crystal structure, potent and US28-specific tool compounds are still scarce. Thomas Michael Frimurer. a, High content microscopy of Flag-HA-BARD1 accumulation at IR-induced DNA DSBs. All rights reserved.Friedrich-Alexander-University of Erlangen-Nürnberg We used a homology model-based approach to identify small-molecule pharmacological tool compounds for the receptor. Zach Gerhart-Hines – Environmental control of adipose tissue metabolism and systemic energy homeostasis. Functional analysis of ion channels is typically conducted by electrophysiological means, using either planar or conventional patch-clamping devices [5][6][7], or based on fluorometric readouts and ion-selective fluorescence indicators [8][9][10][11][12]... FFAR1 is a prime example of this, as it appears to possess at least three very distinct binding sites for agonists: the interhelical site for the hydrophobic para-substituted O-phenyl-alkyl acids, such as TAK-875 and MK-8666; an extrahelical lipid-exposed site for meta-substituted O-phenyl-alkyl acids, such as AM-5262 and AP8; and a solvent-exposed extracellular site with more polar properties (Fig. Recently, we identified monoterpenes, e.g. Thomas Risum Plath Frimer. See more Prof. Anja Groth holds a PhD in Molecular Biology from University of Copenhagen (2004) based on her research on genome stability at the Danish Cancer Society with Drs. Blegdamsvej 3B, Mærsk Tårnet, 6-7-, 2200 København N., Maersk Tower, Building: 07-6-75Associate professor and group leader, The Novo Nordisk Foundation Centre for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen (www.metabol.ku.dk).Dr.

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